Galanthamine CAS NO.357-70-0

[Plant sources] Lycoris plants from isolated an alkaloid. [Alias] strong muscle slices尼瓦林, Nivalin; 11 - methyl -3 - methoxy-4a, 5,9,10,11,12 - hexahydro-6H-benzofuranyl [3a, 3,2 -- ef] [2] benzo…

[Plant sources] Lycoris plants from isolated an alkaloid. [Alias] strong muscle slices尼瓦林, Nivalin; 11 - methyl -3 - methoxy-4a, 5,9,10,11,12 - hexahydro-6H-benzofuranyl [3a, 3,2 -- ef] [2] benzo-aza-Zhuo -6 - Hydrobromide alcohol. [Molecular formula and molecular weight] C17H21NO3   HBr; 368.27 [Structure] [Physical properties] as a white crystalline powder; odorless, bitter taste. Soluble in water, slightly soluble in ethanol, not soluble in chloroform, ether. PH = 4.5-6.5, melting point: 258 degrees -264 degrees, loss on drying: Not more than 1.0%, absorption coefficient (50 ug in 1 ml water): the wavelength at 289nm, the absorption coefficient of 80. [Pharmacological actions] but it is easy for the patient tolerance and fewer adverse reactions. AChE inhibitors can improve the animal to be cholinergic mechanisms and human learning and memory function. For anti-cholinesterase drugs, and improve neuromuscular transmission between for myasthenia gravis, progressive muscular dystrophy, polio sequelae, children's cerebral palsy, because the nervous system disorder caused by a feeling or movement disorders, such as polyneuritis. And galanthamine hydrobromide on February 28 was approved by FDA for the treatment of mild to moderate Alzheimer's type dementia. For acetylcholinesterase inhibitors. Through the blood-brain barrier, on the Anti-SARS depolarizing muscle relaxants. On the motor end plate AChR N2 is also excited to have a direct role in neuromuscular transmission can be improved. And must have a central role to be cholinergic. With physostigmine, neostigmine, pyridostigmine compared with its treatment of a wide range of toxicity, drug-like role of a weak base cover short-term [Clinical application of] the main for myasthenia gravis, spinal cord gray and sequelae of quiescent stromal inflammation, but also for children with cerebral paralysis, multiple neuritis, inflammation of spinal nerve root and because of the nervous system caused by disease or injury of the sensory-motor disorders . Mainly for the treatment of clinical Alzheimer's disease, dementia and brain of the pathological changes caused by memory impairment also has obvious therapeutic effect.